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Thursday, January 03 2002
Today I finally received the results of the mineral test half a month ago..
Magnesium levels are normal. Calcium levels are a bit high however.
I've plotted all in two graphs. I've used index values, where 0 means it's the minimum reference value and 100 means it's the maximum reference value. Values above 100 mean that they're elevated beyond reference values and below 0 are below reference values.
From left to right, first the bloodvalues, then the serum values and at the right the intracellular values:
Ofcourse, Ch should have been Cr (Chromium)..
It seems like I have high serum calcium levels, about 50% elevated beyond maxium reference values. This causes the zinc and magnesium deficiency symptoms, because calcium is a strong antagonist of both minerals.
I also seem to be hyperkalemic and have a sodium deficiency.
Selenium, Manganese, Silicium are also very low..
I don't know what to conclude yet..
I will study to see what this means..
Ed,
The Netherlands
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Tuesday, January 01 2002
New hypothesis:
www.vitaroyal.com/MinWheel.html
I just received a very nice chart which maps most mineral
interrelationships..
The minerals
calcium,copper,manganese,arsenic,magnesium,potassium,phosphorous,cadmium
,cobalt,zinc,sodium and iron are shown, mapped on the edge of a circle.
All minerals that are related are connected with lines.
On the lines, there are arrows. An arrow that goes from mineral a to
mineral b, means that mineral a antagonizes mineral b (exclusively, not
the other way around).
Two arrows on the line mean that mineral a antagonizes mineral b and
that mineral b also antagonizes (opposes) mineral a.
The position of the arrow on the line shows how strong the antagonizing
effect is..
So this line means:
Cu --------------->--<----- Fe
Copper antagonizes Iron at about 65%, while iron also antagonizes
copper at about 25% strength..
This means that when you eat too much copper, it wil have a devastating
effect on the iron levels.
Eating too much iron will affect copper levels, but not that heavily..
I know my calcium:magnesium ratio is very bad. Every milligram of
calcium I eat causes hypomagnesia symptoms.
Ca ------------>-<-------- Mg
Calcium has a stronger effect on magnesium (antagonizing) than mg has
on ca.
I also know I'm zinc-deficient, because of the acne I have, which
instantaneously is relieved when I supplement zinc.
I stopped using it for three days now and the acne has returned again.
Ca ---------------->------- Zn
Calcium antagonizes zinc also, but zinc doesn't antagonize calcium !
New hypothesis:
The high-carb diet I've been eating till last year has caused a high
excretion of magnesium, while calcium remained in the body.
Combined with a low-magnesium, high calcium diet.
Result: Very high Ca:Mg ratio (lots of calcium, low magnesium)
The (very) high calcium levels also antagonize zinc levels --> zinc
deficiency
When this is true, I should also consider a manganese deficiency:
Ca ------------------>---- Mn
Calcium antagonizes mangenese at a high strength, but manganese doesn't
oppose calcium..
Because I don't show manganese deficiency symptoms, I think it's no
problem..
I think the macadamia's, walnuts and almonds (high in manganese) must
have prevented problems..
My intracellular and serum mineral levels will be known soon (when I
finally get the results of the tests).
I think they will confirm my hypothesis.. I will let you know..
Depression-Magnesium update:
-------------------------------------------------
My aunt is making progress, she is starting to like her foods again and
has a more positive attitude !
That's only a few days after she started taking magnesium-glycinate !
Enjoy the new year !
Ed,
The Netherlands
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Sunday, December 30 2001
I discovered two new things:
The zinc supplement in a higher dose is now curing my acne ! I now use 60 mg per day.
What's left is pink, flat skin without any acne left. I stopped using the zinc yesterday, because it also contains calcium and the acne is slowly returning.. I will buy a good zinc supplement without calcium and then I can wish my acne farewell !
I'm currently on a low calcium diet. Only about 100mg a day. I only eat beef (I can eat it now without getting more acne, because of the zinc), chicken, turkey, butter, mushrooms (low-calcium) and coconut-meat. I supplement 600mg of Magnesium and this works perfectly. No more brain fogs whatsoever.. I hope I will receive the test results soon of the intracellular mineral test, so we can start a treatment (Magnesium IV I hope).. I can't stay on low-calcium for ever, because my bones will start to demineralize.
On this low-calcium diet I decided to try the DMSO, because I thought that maybe I couldn't tolerate DMSO anymore because of the increased cell permeability, which when combined with a high calcium intake causes excessive calcium influx. Well, I tried it and I can conclude I can tolerate DMSO and MSM again !
I will soon also try the lipoic acid and the glutamine, which I also couldn't tolerate. I thought it was a liver problem, but now I think my liver is OK and that the dizzyness, brainfogs, energy drops and bad sleep are caused by these supplements causing a change in calcium metabolism. Now I've exclude the calcium from the diet, I think I can tolerate the supplements..
Lipoic acid is known to increase glutathione synthesis.. Low-magnesium causes low-glutatione production, so this may counter it..
I also learned that eating Ca:Mg in 2:1 will cause a negative uptake of Magnesium (more is excreted in urine than is absorbed). An ideal ratio would be close to 1:1.. So when you eat 1000mg of Calcium, it would be very wise to also eat 1000mg of Magnesium, because you will otherwise get a magnesium deficiency, of which the symptoms are not really nice..
Depression Cured
A friend of mine was suffering from depression, so I sent him some of my magnesium tablets.. Within a couple of days he was cured.. When he lowered the dose, the depression returned so he came by to get some more.. It's now completely under control by taking 1000mg of Magnesium-glycinate daily..
Well, that's it for today..
I wish you all a happy and healthy new year !
Ed,
The Netherlands
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Thursday, December 20 2001
Doing fine the last couple of days. I've restricted my Calcium intake to 100-200mg per day. That makes a huge difference. No more brainfogs anymore.
In the morning I couldn't tolerate any Calcium as it would normally cause a brain fog that lasts for about 2-3 hours.
The last couple of days I've been eating only three things: Chicken/turkey meat 600 grams per day, butter 200 grams per day, some coconut meat. All I drink is water.
It's a virtually zero-carbohydrate diet and I feel very well.. This proofs again that carbohydrates are not needed at all.
After checking the nutritional status of this diet , I did add a multivitamin supplement.
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Sunday, December 16 2001
The cure for hypoglycemia and Diabetes II
Additional Notes
You might wonder: Why doesn't anybody know this ?
Why isn't there a single testimonial on the entire internet ?
This might introduce some scepticism, but I will show you why it shouldn't :
For one: People don't know about the Mg-diabetes relation because of the same reasons as why most people don't know the SCDiet
For two: I think nobody has ever followed exactly the right protocol..
The right protocol in theory would be:
* A very low-carb diet
* High Mg supplementation by IV (maybe 4.5 g a day, maybe less)
* Perhaps Boron to decrease urinary losses
When, over time, the intracellular Mg is repleted and the insulin resistance has disappeared, it's important to:
* Stay on a relatively low carb diet. Eating bread and fruit juices again will reinitiate the vicious cycle
* Monitor your intracellular Mg levels periodically
When you think of it: I think nobody has followed this protocol in the entire world..
Perhaps, I will be the first one to try it..
I will have to find a doctor who agrees with me and is willing to administer these high levels of Mg.
I'm beginning to discover I can't handle much more than 600mg of oral Mg daily..
Above that level, even the well-absorbed Mg-glycinate causes diarrhea.
So I think I will need Mg by IV anyway..
Let me know what you think of it..
I also found a better study that shows in vivo (instead of in vitro) that glucose causes Mg excretion. It can also be caused by excessive alcohol intake or diuretics (water excretion pills) or specific medicine like Cisplatin.
Info | References | Printable PDF
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Saturday, December 15 2001
We've made nice progress in the theory:
The Magnesium-glutathione link makes a lot of sense..
I was able to tolerate DMSO and MSM.
After March this year I started to develop extreme hypoglycemia and also hypomagnesemia symptoms.
I couldn't tolerate any MSM and DMSO anymore since then..
So, I now know what caused all symptoms:
Excessive use of sugars (glucose+fructose in grape juice) caused excretion of magnesium and other essenital minerals, but not Calcium.
Results
- Low Mg, Normal/High Ca
- Low intracellular Mg, High Ca
- Mast cells explode too soon: Allergy reactions
- Insulin resistance because of low Mg -- Hypoglycemia -- Vicious Cycle
- No more Mg absorption from intestinal tract -- Vicious Cycle
- Low Mg causes depletion of glutathione -- Low glutathione
Resulting condition:
Hypoglycemia, allergies, can't tolerate sulfur-foods (garlic,onions,asparagus) and MSM,DMSO
Solution:
Magnesium supplemention or IV, glutathione supplementation (expensive), very low-carb diet to prevent hypoglycemia vicious cycle
It all fits.. I hope this is it..
Read the related studies here:
www.newtreatments.org/Hypomagnesia/ga/261
Quotes:
''on the Mg-deficient diet. In association, substantial losses (approximately 50%) of RBC glutathione occurred during the 2nd and 3rd wk.''
''This
study shows that low magnesium levels can induce such excessive NO
production that even the glutathione in the red blood cells is damaged.
These could provide some possible explanations for why magnesium seems
to protect the arteries.rd wk.''
Another quote from www3.sk.sympatico.ca/riverien/Nutri_understanding_immunity.htm :
Glutathione is the regenerator of immune cells. Low levels are associated with premature aging and death.Glutathione is composed of three amino acids- cysteine, glutamic acid and glycine. It is produced in every cell with the aid of selenium, magnesium and vitamin C and is abundantly found in foods. Optimal levels make immune cells extremely efficient. Glutathione sources include cruciferous vegeatbles brussels sprouts, cabbage, cauliflower and broccoli. Avacados are one of the richest food sources of glutathione.
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Saturday, December 15 2001
The diabetes II hypothesis is finished !
I show a copy of what I sent to the Healing Crow Community:
I think I've finally found some concrete evidence that Mg can cure hypoglycemia !
I was first discouraged by this information here:
www.newtreatments.org/ga.php3?linkid=142
In efforts to clarify the relationship between insulin resistance and magnesium, several research groups have examined the effects of magnesium supplementation and glucose
handling. Paolisso et al conducted a double-blind, randomized, crossover study to test the impact of magnesium supplementation on, among other factors, insulin resistance in
elderly individuals. They provided subjects with 4.5 grams magnesium daily for four weeks, which resulted in a significant increase in erythrocyte magnesium concentrations. This
intervention also resulted in an improvement in insulin sensitivity, and this improvement correlated with the improved magnesium status.115
Unfortunately, similar improvements in glucose control were not found in a study of magnesium supplementation in people with type 2 diabetes. While Eibl et al showed that oral
magnesium supplementation (30 mmol/day) for three months resulted in a significant improvement in plasma magnesium levels, this improvement was not sustained following
discontinuation of magnesium, and no significant changes in the metabolic control of blood sugar were observed.116
end quote
Summary:
Study one shows that intracellular Mg has really increased. This results in improved insulin sensitivity !
Study two shows that plasma Mg has increased, but no changes in blood sugar control were observed..
I decided to take a look at the studies myself. I found them in Medline..
The first study:
www.newtreatments.org/ga.php3?linkid=268
They *administered* 4.5 g/d Mg, I assume by IV
The second study:
www.newtreatments.org/Hypomagnesia/ga/269
They used an *oral* Mg supplement.
This difference explains why the 2nd study didn't show an improvement:
* Oral Magnesium is not very well absorbed
* 4.5 g/day is a *LOT* when taken orally, so I assume they used a much smaller amount (of which not all is absorbed)
* Experiences show that only specific forms of oral Mg end up *IN* in the cell and thus increase intracellular Mg, which eventually decreases insulin resistance
When you read the remaining info on Mg, you can only conclude that Mg *CAN* decrease insulin resistance (increase insulin sensitivity) and *MAY* cure diabetes II !
Further quotes from: www.newtreatments.org/ga.php3?linkid=142
Available research suggests an association between magnesium deficiency and insulin resistance. In two patient populations normally associated with insulin resistance,
overweight and type 2 diabetic individuals, magnesium deficiency is a relatively common occurrence.69,70 Depletion of intracellular free magnesium has also been found to be a
characteristic feature of insulin resistance among subjects with essential hypertension.110
Nadler et al reported a decrease in insulin sensitivity with magnesium deficiency in all subjects studied.111 Humphries et al reported a clear association between the lowest
consumption of dietary magnesium and the highest degree of insulin resistance among non-diabetic subjects.112 Dominguez et al confirmed this observation, finding that among
both normotensive and hypertensive subjects, a higher magnesium level corresponded to a greater degree of sensitivity to insulin.110 Looking at this association from another
perspective, research indicated an infusion of insulin lowered the ability to accumulate intracellular magnesium, and this response to insulin might be even more exaggerated
among individuals with higher degrees of insulin resistance.113 Lefebvre et al, in their evaluation of magnesium's role in glucose metabolism, concluded, ''...magnesium
deficiency results in impaired insulin secretion while magnesium replacement restores insulin secretion. Furthermore, experimental magnesium deficiency reduces tissue sensitivity
to insulin.''114
end quote
So, I now know what causes hypoglycemia and diabetes II..
CAUSE:
* High consumption of bloodsugar raising foods (sugars, but also starches like potatoes, etc)
* Glucose causes increase of intracellular Calcium and decrease of Magnesium 1 Barbagallo 1994
* Low intracellular Magnesium causes insulin resistance and also alters pancreas insulin secreting cells
TREATMENT:
* Low-Carb diet to prevent further Mg excretion, because every gram of glucose increases bloodsugar levels for a long period of time
* Effective Magnesium repletion using a good oral supplement or preferably a chronic administration of Mg by IV for a couple of weeks.
(Perhaps Boron supplements when there is still high Mg excretion)
Ref 1:
www.newtreatments.org/ga.php3?linkid=112
It's long been known that sugar causes these nutrients to be lost in the urine, but the calcium level in the blood hardly varies. However, recent nuclear magnetic resonance
imaging studies show that the blood sugar level determines calcium and magnesium levels inside the cell. The studies found that the higher the blood sugar, the more calcium
and the less magnesium there is within living cells (Barbagallo 1994).
Barbagallo 1994: www.newtreatments.org/Hypomagnesia/ga/270
Ref 2:
www.newtreatments.org/ga.php3?linkid=112
In rats, permanent high insulin levels developed after a time proportional to the amount of sugar in their diets. Although their insulin levels normalized when sugar was withdrawn,
the hyperinsulinemea reappeared in days when sugar was reintroduced, so the damage is permanent (Yudkin 1972). Significantly, sugar in the diet of rats reduced their life span
(Dalderup 1969). In humans, non-insulin dependent diabetes can be controlled by diet and exercise, but control is lost if the diabetics return to their old ways. Sugar in the diet
causes permanent injury to the calcium channels of the cells.
In fact it's like this:
Excess carbohydrates cause hypomagnesemia.
Hypomagnesemia causes :
* Diabetes II (and overtime diabetes I because high blood sugars are toxic for pancreas cells)
* Heart diseases
* Severe depressions
* Strange or violent behaviour (some studies suggest that 80-90% of the prisoners are in fact hypoglycemics and thus suffer from hypomagnesemia)
* Many other problems I forgot
Thanks for reading,
I hope I am right about this and that the damage is *not* permanent as Yudkin says in Ref 2.
Ed,
The Netherlands
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Thursday, December 13 2001
Updated Mg-supplementation protocol:
- Instead of 200mg portions, take 100mg portions every hour. You can do this by breaking the tablets in two pieces.
I was still experiencing diarrhea and this last step finally got rid of it.. I feel I'm improving a lot now. Last week I've been very energetic, almost no brain fogs, etc.
Only in the morning there is still a feeling of irritability. This resides when I've had my 200mg of Mg.
I can conclude that the Boron is doing its magic !
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Tuesday, December 11 2001
Somebody in the newsgroup reacted:
{THIS is scary - increases estradiol!!!!!!!!!}
It depends on how low or high current estradiol production is..
For example, when serum Copper levels are low, estradiol production is diminished..
And also, when you eat some fruit and honey, you will easily reach the 3-4mg of Boron..
That makes me think: We can assume that the people in the study ate a high-carb diet, so they ate more Boron than I did.
So, if they already ate 3mg and supplemented another 3mg, it might be safe for me to supplement 6mg..
Also, I think it's a less evil than taking antibiotics or doing nothing..
So, it doesn't really scare me..
I've been thinking some more:
I think I know now why aspartame has such a devastating effect on my sleep right now..
Even a couple of milligrams, causes me to sleep zero minutes.
I think it's because also in the brain the Mg/Ca ratio's are very low.
When aspartame comes around and starts to increase the Ca-influx, only a small amount extra of Ca will cause excitation of the neurons..
That way, you feel sleepy, but your brain keeps on sending signals (firing neurons).. It's impossible to get to sleep then..
Do you think it's safe to chew on Mg-glycinate tablets ? (i.e. are there any ingredients in there that might be bad for your teeth)
I think they will be absorbed better that way and perhaps a small part can be absorbed below the tongue..
I am also considering to try the DMSO transdermal application of Mg. To see if that makes a difference..
I can also ask one of the physicians (alternative medicine) someone gave me a list of, to do a Mg-IV. It costs less than $50, so it's worth the try..
I've also upgraded my Mg-supplementation protocol..
- Don't eat two hours before you go to bed.
- Be sure to take at least 2 x 200mg after you last meal before going to sleep.
I noticed this last night.. Even though I ate only meat (at 11mg Ca/100g) and 50g of brocolli, for in total less than 50mg Ca, I haven't slept till 5:00..
That's when I decided to chew up a half Mg-glycinate tablet. And within half an hour I fell asleep..
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Monday, December 10 2001
Below, you find a message I posted in the Healing Crow Community. Somebody who is also suffering from hypomagnesemia thinks it's caused by bacteria, but I doubt it:
I think the Boron IS making a difference..
The last three days I have been feeling a lot better than before..
Heart arhithmia and muscle spasms are virtually gone, while I haven't increased the Mg supplementation.
www.ithyroid.com/boron.htm
The Boron info on Ithyroid also shows that Boron reduces serum Calcium levels.
Because Ca is the antagonist of Mg this will increase serum Mg levels and over time also intracellular Mg levels I guess..
A quote:
{The following study is a gold mine. The study shows that boron supplementation increases estradiol and testosterone and for reasons given above I believe that these results
suggest that boron might be deficient in hyperthyroidism. Additionally boron was shown to decrease plasma concentrations of calcium. High calcium levels may be associated with
increased heart rate. Since calcium and magnesium act as antagonists, this reduction of calcium by boron may allow magnesium levels to rise and thereby lower the heart rate and
muscle cramps.
Additionally boron was shown to increase plasma copper, copper-zinc superoxide dismutase (SOD is one of the body's most important free radical scavengers), and ceruloplasmin (a
protein which transports copper). Here is direct evidence that boron is essential for copper metabolism and therefore quite probably for the correction of hyperthyroidism and possibly
hypothyroidism.
Furthermore, the study offers a possible explanation for why estrogen may slow thyroid function: it increases plasma copper, SOD, and ceruloplasmin. Boron also increased these
variables whether estrogen was administered or not. }
I also found a thread on magnesium and tricarballylate:
groups.yahoo.com/group/interven/message/8842
A quote (concerning autism):
{Since we started Tasya on ProBio Gold from Kirkman, we've noticed a
substantial lessening of the brief myoclonics she had while falling asleep
during naps and while waking up in the morning. My feeling is that she is
finally absorbing the magnesium as we destroy the tricarballylate producing bacteria.}
I haven't been able to find any other information on this subject..
I personally think it's a bit fuzzy, especially because we can assume that the Mg *IS* absorbed, because it does help and it is bound to an amino-acid..
It might be the cause of the Mg-deficiency in the first place, but it can't explained the sustained hypomagnesemia when you're supplementing Mg-glycinate.
So, I will keep you updated on the Boron.. I think this might be the answer for me (and for you a part of the answer, because it doesn't explain the maldigestion of fats, etc)..
About the brocolli : You will need to dose the calcium in foods very carefully..
Use my nutrient list here: www.scdiet.nl/nutrients.php?v18=on&v20=on
I can't tolerate more than 200 g of brocolli, which equals about 100mg calcium per meal.
So decrease the amounts of veggies and other calcium containing foods to about 100 mg Calcium per meal.
I don't think it's the bacteria that cause the bad sleeps.. I know for sure it's the Calcium in the foods..
It's not a wise idea to starve yourself..
That's it for now.. I will keep you informed about the Boron,
Ed,
The Netherlands
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